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View details for DOI 10.1371/journal.pone.0148911

View details for Web of Science ID 000371219000032

View details for PubMedID 26882224

Intraoperative tracheal injury is a rare but potentially devastating complication. Transhiatal esophagectomy should be avoided in patients with proximal esophageal tumors who underwent neoadjuvant therapy, and percutaneous tracheostomy should be avoided in patients with short, thick necks. Early recognition leads to improved outcomes. Patients present with a sudden loss in airway pressure, air leaking into the operative field, or mediastinal and subcutaneous emphysema. Treatment starts with airway control. Primary buttressed repair is recommended, through either a left cervical incision for proximal injuries or a right thoracotomy for distal injuries. Nonoperative management has been used safely in select patients injured during intubation or tracheostomy.

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View details for Web of Science ID 000359891100004

View details for PubMedID 26210921

Oesophageal cancer is the eighth most commonly diagnosed cancer worldwide, and there is a need for biomarkers to improve diagnosis, prognosis and treatment. Sulfatases 2 (SULF2) is an extracellular endosulphatase that regulates several signalling pathways in carcinogenesis and has been associated with poor prognosis. This study evaluates the relationship between SULF2 expression by immunohistochemistry and overall survival in patients with oesophageal cancer.Cohort study.Single tertiary care centre.We included patients who underwent esophagectomy for invasive oesophageal adenocarcinoma and squamous cell carcinoma at a tertiary care centre from 1997 to 2006. We excluded patients with recurrent oesophageal cancer or less than 3 mm invasive tumour on HE stained slide. A section from each paraffin-embedded tissue specimen was stained with an anti-SULF2 monoclonal antibody.A pathologist blinded to overall survival determined the percentage and intensity of tumour cells staining. Vital status was obtained through the Social Security Death Master File, and overall survival was calculated from the date of surgery.One-hundred patients with invasive oesophageal cancer were identified, including 75 patients with adenocarcinoma and 25 patients with squamous cell carcinoma. The squamous cell carcinoma samples had a higher mean percentage and intensity of tumour cells staining compared with the adenocarcinoma samples. After adjusting for age, sex, race, histological type, stage and neoadjuvant therapy, for every 10% increase in percentage of tumour cells staining for SULF2, the HR for death increased by 13% (95% CI 1.01 to 1.25; p=0.03).The majority of adenocarcinoma samples and all of the squamous cell carcinoma samples had SULF2 staining. The percentage of tumour cells staining for SULF2 was significantly associated with overall survival. Thus, SULF2 is a potential biomarker in oesophageal cancer and may have an important role in the management of patients with this disease.

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Best Western Plus® Quartier Latin Pantheon

Executive Guest Room

Superior Guest Room

Guest Room

Guest Bathroom

City View

Lobby

Hammam

Breakfast Seating

Breakfast Bar

Business Corner

Lounge

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160.55

CHECK-IN

2:30 P.M. CET

Toll Free Reservations (US Canada Only)

1(800) 780-7234

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11:30 A.M. CET

Hotel Direct Number

+33 1 43 31 25 64

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Ideally located in the heart of the Latin Quarter, within walking distance from the rue Mouffetard, The Pantheon, the Botanical Gardens and the National History Museum, and Notre Dame Cathedral.

The 37 guest rooms entirely air conditioned in 2005 and redecorated in a modern style in 2006, are all complete with private en suite bathrooms equipped with a bathtub or a shower and hairdryers, remote control cable TV, direct dial phones, automatic alarm clocks, air conditioning and a wireless Internet connection.

Access : Métro : 7 Place Monge 10 : cardinal Lemoine Bus : 47, 67, 89 Gare : Austerlitz Gare : Lyon.

Latest Reviews

We stayed for 3 nights. The location was just fantastic, the main reason we choose the hotel. 3 minute walk to Place Monge metro and a couple of minutes to rue mouffetard and all it's restaurants and...

We arrived after a late train journey at the hotel. Sadly we were met my quite a grumpy male receptionist who could barely manage a smile despite our efforts to be nice . The hotel Itself was located...

There were 12 of us on a weekend in Paris and this hotel was great location, clean, and nice rooms. Some staff were excellent others not so great. Beautiful bakery across from hotel where hot drinks...

This property has the potential to earn a higher rating; however, their "free internet" was iffy at best and usually none-existent. This was a major nightmare for my travel mate who was on a working...

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